Unit Head: Edith Monteagudo [Ph.D.]

Nuclear Magnetic Resonance (NMR) spectroscopy is a powerful tool for the study of structural biology, metabolomics and analytical chemistry. We have developed methods for helping different phases of drug discovery, from hit identification and validation to lead optimization.

IRBMAs part of the Preclinical Research Unit, the NMR group also focuses on the development and deployment of NMR protocols to support preclinical studies. The team has significant expertise in the use of NMR spectroscopy for the investigation of drug mode of action in biofluids, cells, bacteria or parasites. We have also developed a robust NMR-based metabolomics platform to identify biomarkers of pathology in minute samples of biofluids and in a cost-efficient manner.

NMR Capabilities
Our NMR team can provide you with a flexible toolkit throughout your project, including:

  • Structural, purity and stability checks;
  • Aggregation state analysis;
  • Determination of macromolecular 3D structure and dynamics;
  • Protein/ligand interaction studies;
  • Fragment-based drug discovery;
  • Plasma protein binding of drug candidates;
  • Metabolism and disposition of fluorine-containing drug candidates;
  • Discovery of biomarkers in biofluids, cells and tissue extracts;
  • Mode of action of drugs using metabolomics.