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Understanding a compound’s properties is key to developing a successful drug

ADME DMPK

ADME (absorption, distribution, metabolism and excretion) properties are crucial for understanding the safety and efficacy of a drug candidate, increasing the likelihood of a successful program. The DMPK (drug metabolism and pharmacokinetics) properties of the product determine how much of the drug will reach the target, and the duration it will stay in the target area.

Utilizing state-of-the-art technology, our experienced DMPK team conducts both in vitro and in vivo studies. These support the selection of compounds with optimal ADME properties for further development as drug candidates.

We support all standard DMPK assays used to profile compound candidates from hit identification to IND filings, and generate tailored assays that meet your project needs. Our experienced scientists create innovative solutions to identify xenobiotic and endogenous metabolites from biological samples, and identify biomarkers using targeted or untargeted analysis.

We have big Pharma expertise in qualitative and quantitative analyses of small molecules, peptides and proteins in biological fluids and tissues. Our operations are supported by integrated and automated sample processing and analysis platforms. This minimizes human error and provides highly reproducible and accurate data to help meet the tight timelines required in drug discovery.

Our skilled principal scientists provide ongoing scientific support, explain results, identify solutions to challenges, and suggest how to move forward. They can also support the development of novel analytical methods for project-specific purposes.

IRBM’s ADME – DMPK facilities have passed evaluations from numerous organizations, including world-class pharmaceutical companies, and are compliant with all EU regulations.

Our capabilities

  • Physicochemical profiling
  • In vitro drug metabolism assays
  • In vitro and in vivo Met ID and HRMS-radioprofiling
  • PK in rodents/lagomorphs, even at microdoses
  • PK/PD
  • Human prediction
  • Formulation support
  • Metabolomics by NMR/LC-MS, both non-targeted and targeted
  • Biomarkers
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