We can screen proprietary phage libraries displaying
We can also design and generate custom libraries that are best suited for the target of interest.
In the field of macromolecule discovery, the possibility to explore combinations of amino acid and/or binding determinants by rational design is often hampered by the lack of previous knowledge or by limitation in synthetic technologies.
The availability of the above mentioned libraries and the generation of target-specific libraries allows the identification of hit molecules to be further developed as therapeutics, diagnostics or tools for biology discovery. We can apply display technologies to the discovery of biologically relevant compounds, such as:
- Identification of peptides with improved receptor affinity for therapeutics development in IP free areas
- Identification of peptides with improved target affinity for PPI disruption for further development (e.g. through peptidomimetic approaches)
- Identification of antibodies for use in immuno-oncology.
The interplay between molecular biology, display technologies, testing and synthetic biology is key for the discovery of novel entities able to open innovative avenues toward unprecedented therapeutic approaches. At IRBM, we offer all these capabilities available under one roof.