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Small Molecule Chemistry - IRBM
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Streamlined workflows maximize efficiency and reduce time to clinic

Small molecule chemistry

We have a proven track record in identifying, synthesizing and advancing small molecule drug candidates into preclinical and clinical studies, and to the marketplace.  Strong organic chemistry skills underpin everything that we do, and our passionate, international team of chemists has a broad range of expertise. With many of our team having experience in either global pharmaceutical companies or in a CRO setting, we are confident in delivering world-class results that fit our partners’ needs and timelines.

Our synthetic designs employ tailored ‘fit-for-purpose’ chemistries that align with your project needs. We use synthetic approaches ranging from tried-and-tested chemistry transformations, to state-of-the-art organic chemistry methodologies. Our broad range of chemistry experience, spanning heterocycle-based bioactive compounds to more challenging chemical spaces, ensures that your project is in safe hands.

As a group, we have experience in all phases of drug discovery, and our multidisciplinary approach ensures your project advances swiftly through the stages of drug discovery. Our streamlined workflows are designed to generate results in an efficient and cost-effective manner. We have a strong background in performing challenging chemical syntheses, including nucleosides, deuterated steroids and bioactive heterocyclic compounds. Our goal is to deliver outstanding compounds capable of successfully driving your development program.

Small Molecule Chemistry IRBM

Synthetic approaches

  • Chiral and high-pressure hydrogenations
  • Parallel transition metal catalyzed chemistry
  • Photoredox/SET technologies and decarboxylative cross-coupling reactions

Streamlined workflows

  • Parallel synthesis technologies and robotic liquid/reagent handling
  • Preselected and curated reagent sets
  • Centralized automated compound purification and analysis
  • Automated QC protocol and in-house software for library analysis
  • Scale-up chemistry up to 20L reaction volumes for research intermediates and non-GLP API
  • Research scale chiral separations by SFC

Computational chemistry support

  • HTS follow-up (e.g. clusterization, similarity searching, hit validation)
  • Ligand/structure based virtual screening
  • De novo design based on prior art
  • Hit to lead chemistries – often including small compound libraries to generate early SAR
  • Multidisciplinary lead optimization
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