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Jr Research Scientist – Protein Production

NMR Unit

IRBM is a scientific contract research organization (CRO) that stands at the forefront of drug discovery, leveraging a single, unified research facility, located in Pomezia (Rome), Italy, to accelerate team-based breakthroughs and improve efficiencies from initial concept to pre-clinical candidate.

With a history of contributing to several approved drugs, and its own internal pipeline of oncology and other therapeutic assets, IRBM is powered by deep collaborations and decades of expertise from leading global institutions. Our comprehensive in-house capabilities assist partners in achieving key milestones and progressing towards clinical readiness, positioning IRBM as a major player in driving innovation in the pharmaceutical and biotech fields.

Job Description

We are looking for a passionate and talented scientist who has an interest in structural biology and structure-based drug discovery. The successful candidate will work in a highly collaborative research environment and will be in charge of producing high-quality protein samples for structural biology projects and biophysical applications. The applicant must have solid training in protein biochemistry, protein overexpression in bacterial/eukaryotic systems and experience in protein purification. The new resource will work closely with the NMR group and will assist in sample preparation for spectroscopic studies. Additionally, the successful candidate will be responsible for preparing protein standards for method development and biological reagents for biological assays and screenings.

Key responsibilities

  • Apply, optimize, and innovate protein purification processes. Maximize protein yields, activity, stability and purity
  • Execute and troubleshoot bench experiments carefully and precisely. Apply standard molecular biology, biochemical and cell biology techniques to achieve research goals
  • Sustain protein production for internal and external projects
  • Perform ongoing care and upkeep of instruments used primarily for protein production
  • Provide support to the NMR group and participate to research activities aimed at improving existing and/or developing new tools for structural biology
  • Perform technical evaluation of research experiments and results, perform data analysis and keep detailed records of data
  • Present data and reports on project status to multidisciplinary teams and external collaborators

Competencies/skills

  • Experience with expression and purification of recombinant proteins from  coliand mammalian cultures
  • Hands on experience in various chromatographic purification techniques, including but not limited to affinity, ion exchange, and size exclusion
  • Knowledge of cloning techniques for plasmid construction
  • Hands on experience in insect cell-based protein expression is not essential but will be considered a plus
  • Extremely organized and able to efficiently manage time and operations considering both long-term projects and day-to-day responsibilities
  • Highly collaborative, team-oriented, and able to learn quickly
  • Outstanding oral and written communication skills, particularly when collaborating with other teams with limited knowledge of your area of expertise
  • Excellent knowledge of spoken and written English is mandatory

Qualifications

Required: Ph.D. in Biological Sciences (Structural Biology, Biochemistry, or related fields) or equivalent experience in an industrial setting

During the job interview we will evaluate candidates’ experience and the job offer will be commensurate.

We thank all applicants for their interest, candidates selected for interviews will be contacted.

IRBM considers all qualified applicants without discrimination, including on the basis of race, gender, age, disability, gender identity or expression, national origin, religion, sexual orientation, or other protected classes. We nurture an inclusive culture where everyone can show their full potential and enjoy a fulfilling career.

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