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Junior Research Scientist

Peptide Chemistry Unit

IRBM is a scientific contract research organization (CRO) that stands at the forefront of drug discovery, leveraging a single, unified research facility, located in Pomezia (Rome), Italy, to accelerate team-based breakthroughs and improve efficiencies from initial concept to pre-clinical candidate.

With a history of contributing to several approved drugs, and its own internal pipeline of oncology and other therapeutic assets, IRBM is powered by deep collaborations and decades of expertise from leading global institutions. Our comprehensive in-house capabilities assist partners in achieving key milestones and progressing towards clinical readiness, positioning IRBM as a major player in driving innovation in the pharmaceutical and biotech fields.

Job Description

We are seeking a talented Master’s-level peptide chemist with a background in solid and liquid phase chemistry of peptides, native chemical ligation of small proteins, as well as expertise in organic synthesis to advance internal and external peptide drug discovery programs. In this laboratory-based position, the candidate will be involved in the planning and execution of multi-step synthesis, purification and analytical characterization of complex peptides to generate new chemical entities to achieve agreed upon objectives in a timely manner. The successful candidate will communicate effectively with internal and external collaborators to achieve project objectives and will work efficiently in a multi-disciplinary team environment.

Key responsibilities

  • Develop and execute synthetic strategies towards complex molecules using state-of-the-art synthetic methodologies.
  • Analyze and identify compounds using different purification and spectroscopic techniques.
  • Contribute to scientific strategies and goals within a project team setting.
  • Present data and reports on project status at individual and group meetings.
  • Conduct laboratory operations in a safe manner. Exhibit safety awareness and safe work practices; comply with all safety requirements according to Italian laws.

Competencies/skills

  • Experience in peptide chemistry for the design/synthesis of complex peptides including peptide conjugates, macrocycles, small proteins
  • Experience in synthetic route design and synthesis of amino acids and building blocks
  • Proficient in experimental design and laboratory equipment with a preferential knowledge on the use of peptide synthesizers
  • Good laboratory skills and knowledge of common purification techniques (HPLC, IEX, GPC) and analytical techniques (UPLC/HPLC and mass spectrometry)
  • Knowledge and experience in structure elucidations of organic molecules by NMR and MS
  • Outstanding organizational skills.
  • Good oral/written communication In English
  • Good team player

Qualifications

Required: Master’s Degree in Chemistry or a related discipline with 2+ years of relevant research experience.

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