skip to Main Content

Jr. Research Scientist at IRBM, Structural Biology Unit, Computational Chemistry & Structural Biology Department – Ref. 167 A

July 22nd, 2021

Position: Jr. Research Scientist at IRBM, Structural Biology Unit, Computational Chemistry & Structural Biology Department – Ref. 167 A

IRBM is a drug discovery and development company with a track record of success in accelerating and executing the translation of novel discoveries into clinically relevant therapeutic modalities, including small molecules, peptides and monoclonal antibodies. IRBM is headquartered in Pomezia (Rome), Italy and provides several integrated pre-clinical laboratory services across the entire drug discovery process, ranging from target validation to clinical candidate molecule selection. The company operates through collaborations with a number of Pharmaceutical companies, Biotechs as well as research institutes and non-profit foundations working in a range of disease indications. IRBM is committed to the discovery and development of novel therapeutic agents that can help fight and cure diseases.

Job Description

We are seeking an experienced and talented scientist who is interested in structural biology and structure-based drug discovery. The successful candidate will work in a highly collaborative research environment and will be responsible for the production of high-quality protein samples for NMR-based structural biology projects. The applicant must have a solid training in protein biochemistry, protein overexpression and purification in E. coli and experience in characterizing protein interactions. The new resource will work closely with the NMR group and will provide support in sample preparation for spectroscopic studies. In addition to these tasks, it is expected that the successful candidate will gradually learn how to acquire and analyze NMR data independently to assist the team’s needs. Therefore, possession of an enthusiastic and proactive attitude towards learning is a must.

Key responsibilities

  • Develop, optimize and innovate protein purification processes. Maximize protein yields, activity, stability and purity for NMR-based projects
  • Design, troubleshoot and execute bench experiments carefully and precisely. Apply standard molecular biology, biochemical and cell biology techniques to achieve research goals
  • Sustain protein production for internal and external needs
  • Perform ongoing care and upkeep of instruments used primarily for protein production
  • Provide support to the NMR group and participate to research activities aimed at improving existing and/or developing new tools for structural biology
  • Perform technical evaluation of research experiments and results, perform data analysis and keep detailed records of data
  • Present data and reports on project status to multidisciplinary teams and external collaborators

Competencies/skills

  • Experience with expression and purification of recombinant proteins from E. coli and other hosts
  • Hands on experience in various chromatographic purification techniques, including but not limited to affinity, ion exchange, and size exclusion
  • Knowledge of cloning techniques for plasmid construction
  • Extremely organized and able to efficiently manage your time and workflow in regard of both long-term projects and day-to-day responsibilities
  • Highly collaborative, team-oriented, and able to quickly learn and adapt to the team’s need
  • Hands on experience in NMR spectroscopy is not essential but will be considered an asset
  • Outstanding oral and written communication skills, particularly when collaborating with other teams with limited knowledge of your area of expertise
  • Excellent knowledge of spoken and written English is mandatory

Qualifications

Required: Ph.D. in Biological Sciences (Structural Biology, Biochemistry, Biophysics or related fields.

Back To Top