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183 B

Research Scientist

Display Technologies Unit

Research Scientist – Display Technologies Unit – Ref. 183 B

IRBM is an innovative contract research organization working across all aspects of drug discovery and early development for different modalities – small molecules, peptides, RNAs and antibodies. We foster collaborations with organizations from the pharmaceutical, biotech and academic sectors to accelerate drug discovery from target validation and hit identification to candidate nomination. Our 200 plus-strong, multidisciplinary teamwork at a state-of-the-art R&D facility near Rome where projects are carried out “under one roof” enabling rapid cycle times and close integration of the scientific teams. IRBM’s scientists have discovered several drugs that are on the market, and more than 25 compounds have gone into clinical testing. The company was founded in 2010, as a spin-off from Merck & Co. Now in our 12th year as an independent research organisation, we have laid the foundations to become a global centre for excellence in all aspects of drug discovery and early development.

Job Description

We are seeking a talented and highly motivated scientist to join the Display Technologies Unit. The successful candidate will be responsible for driving the execution and expansion of the state-of art methodologies for mRNA display library generation and selection on a target of interest, as well as of functional in vitro and cell-based assays to confirm the biological properties of the selected molecules. S/he will have hands-on peptide discovery training (in academia or industry), preferably with mRNA Display or Phage Display expertise. This individual will play a key role in furthering screening efforts, by conceiving, developing and implementing innovative workflows for mRNA Display and informatic analysis.

The successful candidate is expected to work at the bench and will have plentiful technical skills to independently plan, execute and analyse the experiments agreed upon producing high-quality results. Candidates with prior experience in mRNA Display, Phage Display, molecular biology, biochemistry will be given priority.

Key Responsibilities

  • Design, validate and execute mRNA Display selections with follow-up NGS QC and analysis.
  • Identify opportunities for platform and workflow improvements (e.g. automation) or peptide libraries modifications (e.g. nnAA).
  • Actively and independently contribute to the experimental planning.
  • Generate accurate and reliable set of data working hard at bench.
  • Accurately record, analyze, summarize, and present data when required.
  • Establish productive working relationships with all team members.
  • Maintain high laboratory standards regarding quality and safety.

Competencies/skills:

  • Molecular Biology, Biochemistry, or related discipline
  • Deep and broad understanding of molecular biology, including Next Generation Sequencing (NGS)
  • Proven experience performing affinity selections for mRNA-Display, Phage Display.
  • Critical thinking.
  • Outstanding organizational skills
  • High degree of flexibility and ability to work on multiple projects simultaneously while meeting deadlines.
  • Excellent Data analysis, interpretation, and problem-solving skills.
  • Excellent interpersonal, oral and written communication skills
  • Good knowledge of spoken and written English is mandatory.

Requirements

PhD in Biochemistry, Molecular Biology or related fields with at least 3+years of relevant research experience

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