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Senior Research Associate II – IRBM, Oncology Unit Ref. 188B

IRBM is an innovative contract research organization working across all aspects of drug discovery and early development for different modalities – small molecules, peptides, RNAs and antibodies. We foster collaborations with organizations from the pharmaceutical, biotech and academic sectors to accelerate drug discovery from target validation and hit identification to candidate nomination. Our 200 plus-strong, multidisciplinary teamwork at a state-of-the-art R&D facility near Rome where projects are carried out “under one roof” enabling rapid cycle times and close integration of the scientific teams. IRBM’s scientists have discovered several drugs that are on the market, and more than 25 compounds have gone into clinical testing. The company was founded in 2010, as a spin-off from Merck & Co. Now in our 13th year as an independent research organisation, we have laid the foundations to become a global centre for excellence in all aspects of drug discovery and early development.

Job Description

We currently have an open position for a highly motivated Sr Research Associate II to join our Oncology Unit and support our drug discovery efforts. The individual will execute experiments to test biological hypothesis, to identify new targets and to define the mechanism of action of new molecular entities in Oncology. The successful candidate will work at bench and is expected to provide technical support and supervision to other laboratory members, including introduction and teaching of laboratory techniques and support on the use of lab equipment.

A collaborative attitude and ability to multitask are essential for this position. Candidates with hands-on experience with cell-based assay and cell biology will be given priority.

Required qualifications:

  • Master’s degree in biology, Biochemistry, Biotechnology, or other biological science area.
  • Minimum 5 years of postgraduate research experience with an in-depth knowledge of cancer biology and cell-based assays.
  • Must have a broad experience in cell biology and tissue culture techniques.
  • Experience with standard molecular biology and biochemical techniques (e.g., cloning, nucleic acid and protein isolation from human and animal tissue samples, PCR/qPCR, and Western blot).
  • Experience with relevant experimental techniques to modulate gene expression, such as CRISPR, lentiviral transduction, RNAi, shRNA etc.
  • Experience in bacterial transformation, and restriction enzyme analysis.
  • Excellent organizational and communication skills.
  • Proficiency in IT Tools: MS Office Software (Word, Outlook, Excel, PowerPoint), GraphPad Prism (or similar) for data analysis.
  • Ability to multitask with emphasis on accuracy and attention to details.
  • Flexible, proactive, efficient, and able to work independently with a problem-solving attitude.
  • Strong team player, high-energy and positive personality
  • Working knowledge of English is mandatory.

 

Desirable qualifications:

  • 3+ years of experience in biotech/pharma company with expertise in drug discovery would be a strong asset.
  • Experience establishing and maintaining primary cell lines and organoids.
  • Experience in screening small molecule ligands in microplate-based assay formats to drive Structure-Activity Relationship on purified protein using manual and automated systems.
  • Develop and perform cell-based assay enzymatic (determine enzyme activity and kinetics) and substrate binding assays independently or with other team members as instructed.

 

During the job interview we will evaluate candidates’ experience and the job offer will be commensurate.

We thank all applicants for their interest, candidates selected for interviews will be contacted.

 

IRBM considers all qualified applicants without discrimination, including on the basis of race, gender, age, disability, gender identity or expression, national origin, religion, sexual orientation, or other protected classes. We nurture an inclusive culture where everyone can show their full potential and enjoy a fulfilling career.

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