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Identification by High-Throughput Screening of Pseudomonas Acyl-Coenzyme A Synthetase Inhibitors.

By Turcano, Lorenzo; Visaggio, Daniela; Frangipani, Emanuela; Missineo, Antonino; Andreini, Matteo; Altamura, Sergio; Visca, Paolo; Bresciani, Alberto From SLAS Discovery (2017), 22(7), 897-905. Language: English, Database: CAPLUS, DOI:10.1177/2472555216689283 Pseudomonas infections are common among hospitalized, immunocompromised, and chronic lung disease patients.…

Understanding the Molecular Determinant of Reversible Human Monoamine Oxidase B Inhibitors Containing 2H-Chromen-2-One Core: Structure-Based and Ligand-Based Derived Three-Dimensional Quantitative Structure-Activity Relationships Predictive Models.

By Mladenovic Milan; Patsilinakos Alexandros; Pirolli Adele; Sabatino Manuela; Ragno Rino; Patsilinakos Alexandros; Ragno Rino; Pirolli Adele From Journal of chemical information and modeling (2017), 57(4), 787-814, Language: English, Database: MEDLINE Monoamine oxidase B (MAO B) catalyzes the oxidative deamination…

An efficient liquid chromatography-high resolution mass spectrometry approach for the optimization of the metabolic stability of therapeutic peptides.

By Esposito, Simone; Mele, Riccardo; Ingenito, Raffaele; Bianchi, Elisabetta; Bonelli, Fabio; Monteagudo, Edith; Orsatti, Laura From Analytical and Bioanalytical Chemistry (2017), 409(10), 2685-2696. Language: English, Database: CAPLUS, DOI:10.1007/s00216-017-0213-1 In drug discovery, there is increasing interest in peptides as therapeutic agents…

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