SHP2 as a Therapeutic Target Src homology phosphotyrosine phosphatase 2 (SHP2), encoded by PTPN11, is a ubiquitously expressed non-receptor protein tyrosine phosphatase. It plays a central role in several signaling pathways, including RAS/MAPK, JAK/STAT, and PI3K/AKT, regulating cell proliferation, differentiation,…
Huntington's disease (HD) is a progressive neurodegenerative disease caused by the expansion of a CAG repeat in the huntingtin (HTT) gene, resulting in a huntingtin protein with an expanded polyglutamine (polyQ) tract. Phosphorylation at residue S421 (pS421) affects HTT biology,…
Unlocking New Avenues for IL-11 Therapeutics Interleukin-11 (IL-11), a member of the cytokine family, has been implicated in various disease pathologies, including pulmonary, hepatic, cardiovascular, renal, and intestinal disorders, as well as oncogenesis. Given its pro-inflammatory and pro-fibrotic roles, IL-11…