Biomarkers for Neurodegenerative Diseases: Immunoassays and LC-MS/MS to Track Disease Progression

We recently had our Xtalks webinar on “Biomarkers for Neurodegenerative Diseases: Immunoassays and LC-MS/MS to Track Disease Progression” on the 12th of October, presented by our talented scientists Manuel Daldin and Pamela di Pasquale.

During the webinar, Manuel and Pamela discussed two strategies for monitoring neurodegenerative disease using objective biomarkers that offer new and unique perspectives.

Manuel talked about the development of a single molecule counting (SMC) ultra-sensitive assay to detect fM-level huntingtin (HTT) in human cerebrospinal fluid. The relevance of the antibody and the calibrator analyte selection in the light of HTT biology was discussed, together with the assessment of potential confounding factors when detecting highly diluted analytes in peripheral fluids.

Pamela reviewed mass spectrometry-based methods for the robust measurement of novel investigative biomarkers for the identification of a neurodegenerative disorder. A case study was used to highlight a liquid chromatography-mass spectrometry (LC-MSMS) approach that can follow predictive biomarkers in the context of pantothenate kinase-associate neurodegeneration (PKAN).

To watch this event, visit: https://lnkd.in/gj344mtk