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Be sure to visit posters P225 and P277 at the IX EFMC International Symposium on Advances in Synthetic and Medicinal Chemistry (EFMC-ASMC 2023) in Zagreb, Croatia from 3 – 7 September to learn more about IRBM’s exciting research on novel allosteric SHP2 inhibitors!

📅 Sep 6 at 13.15 – 14.30: Alessio Sferrazza will cover our efforts leading to the identification of potent SHP2 azabicyclic inhibitors showing a novel primary amino group engaging key interactions in the allosteric pocket of the protein.

📅 Sep 6 at 13.15 – 14.30: Alessia Petrocchi will present the discovery of the series that led to I-0436650 a novel, highly potent and orally available allosteric SHP2 inhibitor, that shows efficacy in vivo to treat RAS-driven cancers.

Heidi Kingdon Jones, our Global Vice President of Sales & Marketing will also be attending, and we can’t wait to speak to you about our chemistry capabilities and track record in #drugdiscovery.

Connect with us at, and discover our pioneering project work in cancer, neurodegenerative, Infectious Diseases and many other vital therapeutic areas on our publications page.

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