From marine natural products to macrocyclic peptidomimetics
IRBM would like to announce that on May 25th at 11:30 a seminar will be held in our auditorium.
Discovery of MK-1462: GLP-1 and Glucagon Receptor Dual Agonist for the Treatment of Obesity and Diabetes
The IRBM peptide chemistry team is proud to announce a new publication in ACS Medicinal Chemistry Letters in collaboration with the outstanding drug discovery team at Merck & Co. (Kenilworth, NJ).
IRBM publish malaria breakthrough research in Nature Communications Biology
In a collaboration with Istituto Superiore di Sanità and CNR, IRBM has published research that identified new molecules which block the transmission of the malaria parasite from an infected person to the mosquito, the first step in developing new drugs to eliminate this major infectious disease.
IRBM World Cancer Day & Head of Oncology
This world cancer day we are here to raise awareness about the prevention, detection, and treatment of cancer.
We would like to take this opportunity to welcome our new Head of Oncology Alessandro Carugo, PhD. Prior to joining, Alessandro spent more than 10 years at The University of Texas MD Anderson Cancer Center, a world-renowned institution devoted to cancer patient care and prevention.
We would like to take this opportunity to welcome our new Head of Oncology Alessandro Carugo, PhD. Prior to joining, Alessandro spent more than 10 years at The University of Texas MD Anderson Cancer Center, a world-renowned institution devoted to cancer patient care and prevention.
Discovery and characterization of novel peptide inhibitors of the NRF2/MAFG/DNA ternary complex for the treatment of cancer
Our Peptide Chemistry team, in collaboration with scientists at Merck and Co., reported on the design, synthesis and characterization of potent and stable peptides able to inhibit the binding of NRF2-MAFG heterodimeric transcription factor to Antioxidant Response Element (ARE) DNA sequence.
Targeting of eIF6-driven translation induces a metabolic rewiring that reduces NAFLD and the consequent evolution to hepatocellular carcinoma
At IRBM we are passionate about helping companies develop medicines in a wide range of diseases and our scientists support the fundamental understanding of disease mechanisms. Science is about collaboration, and publication is an integral part of the scientific process.
IRBM & collaborators publish on techniques for characterizing peptides in Type 2 diabetes and a peptide drug discovery program for Huntington’s disease
Nowadays, there is a strong drive to explore new areas of chemical space in search of innovative ways to bind and modulate challenging biological targets. At IRBM our peptide chemistry team has extensive expertise in peptide and macrocyclic drug discovery in various therapeutic areas.
IRBM to collaborate with MSD to develop peptides against coronavirus
Builds on Research to Combat Severe Acute Respiratory Syndrome (SARS)
Rome, Italy – IRBM, a global Contract Research Organization today announced a new research collaboration agreement with MSD (tradename of Merck & Co., Inc., Kenilworth, NJ, USA) to identify and develop novel peptide therapeutics active against different strains of coronavirus, including SARS-CoV-2.
Rome, Italy – IRBM, a global Contract Research Organization today announced a new research collaboration agreement with MSD (tradename of Merck & Co., Inc., Kenilworth, NJ, USA) to identify and develop novel peptide therapeutics active against different strains of coronavirus, including SARS-CoV-2.
In Memory of Maurizio Botta: His Vision of Medicinal Chemistry
IRBM’s medicinal chemists are incredibly proud to have contributed 3 articles to a special issue of the ACS Medicinal Chemistry Letters in memory of Professor Maurizio Botta. Many of our chemistry team were former students of the professor and are therefore thrilled to be part of this tribute.
IRBM supporting the effort to cope with the impact of coronavirus
There are many ways to face the impact of coronavirus. Due to the worldwide pandemic, there is a blood shortage in several hospitals. The staff at IRBM set up, in partnership with Ema-Roma, a Blood Donation Day. This highly worthwhile…
