IRBM, Rainwater Charitable Foundation (RCF, based in Fort Worth, Texas), a private family foundation, and Weill Cornell Medicine (based in New York) announce the start of a multi-year drug discovery collaboration to identify small molecule cGAS (cyclic GMP-AMP synthase) inhibitors for the treatment of tauopathies and other neurodegenerative diseases. Financial details are not disclosed.
IRBM, an innovative contract research organization, today announced it has signed a new agreement with Merck & Co., Inc., Rahway, NJ, USA, known as MSD outside the USA and Canada, to continue their collaboration in the peptide therapeutics area.
The publication describes the discovery of a novel series of Imidazopyrazine derivatives by IRBM’s drug discovery team. This novel series of SHP2 allosteric inhibitors, having an imidazopyrazine 6,5-fused heterocyclic system as central scaffold, showed an excellent potency in enzyme and cellular assays.
IRBM’s Advent, a global leader in viral vector manufacturing, has made thousands of doses of a novel Covid-19 vaccine, called AZD1222, for use by the University of Oxford and AstraZeneca in clinical trials in the UK, Brazil and South Africa.
