Advance Target Validation. Build Disease-Relevant Models. De-Risk Discovery.
IRBM’s Functional Genomics Platform empowers biotech and pharmaceutical companies to make confident, data-driven decisions in early-stage drug discovery. Our integrated approach combines precision genome editing, engineered cellular models, and high-resolution readouts to validate targets, interrogate disease mechanisms, and accelerate translational research. Our services are tailored to meet unique client requirements, ensuring maximum flexibility and efficiency.
We help you ask relevant biological questions and get actionable answers.
Genome Editing & Engineering
- Stable knockouts, knock-ins, and reporter line generation
- CRISPR screening: KO, CRISPRi, CRISPRa
- CRISPR tiling to map functional domains
- Base and prime editing for more accurate gene editing
Engineered Cellular Models
- Custom hiPSC/hESC-derived disease models
- Monoclonal cell lines from primary and immortalized sources
- Isogenic and reporter lines for high-content functional studies
Target Validation Workflows
- Functional assays linked to therapeutic hypotheses
- Pathway deconvolution and mechanism-of-action analysis
- Integration with IRBM’s medicinal chemistry, pharmacology, and biomarker discovery teams
Multi-Modal Data Readouts
- High-content imaging and morphological phenotyping
- Single-cell and bulk transcriptomics (RNA-seq)
- Proteomics and multiplexed readouts
Why Choose IRBM for Functional Genomics?
We are more than a service provider—we’re a scientific partner. IRBM integrates functional genomics into a broader drug discovery ecosystem, enabling continuity from genetic screens to preclinical models. Our team of expert biologists, chemists, and translational scientists collaborates closely with biotech and pharma innovators to drive high-quality target validation and early decision-making.
Our services are designed to integrate smoothly with each client’s research pipeline, adapting to specific project requirements to support efficient target validation and well-informed decision-making in drug discovery.
- Strategic.
- Collaborative.
- Data-Rich.
Applications of Functional Genomics Across Therapeutic Areas
Oncology
Uncover gene dependencies,
resistance pathways, and synthetic lethality
Neurodegeneration
Model disease-relevant biology in
human-derived systems
Rare Diseases
Engineer isogenic pairs to probe
causality and screen interventions
Let’s Accelerate Smarter Drug Discovery Together.
Partner with IRBM to build validated models, uncover functional insights, and move from uncertainty to action in your discovery programs.
Start a conversation.
Great science begins here.