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At IRBM we use our powerful phage display tools to select binding partners for your chosen ligands. We have more than 20-years’ experience in peptide phage display, and we apply our expertise and custom libraries to design screening strategies that will accelerate and advance your drug discovery program.

Whether you are targeting a protein-protein interaction, developing an agonist, antagonist, or delivery agent, we’ll use our broad scientific expertise in phage display to drive your project from phage library screening and affinity selection, through characterization, and development.

Our high-complexity phage display libraries contain more than a billion peptide variants and are available in both linear and Cys-constrained formats. They also include conformational peptide libraries to support any requirement.

Peptides with high affinity and target specificity will be isolated through iterative rounds of affinity selection and screening for identifying the sequence of the binder peptide or protein variants.

In addition, we offer a comprehensive range of modification strategies and analytical tools to ensure your peptides are fit-for-purpose and demonstrate therapeutic attributes.

MODIFICATION STRATEGIES & ANALYTICAL TOOLS

  • In-house libraries, each with > 109 complexity:
    • Linear and Cys-constrained random or conformational peptide libraries on M13 pVIII- and pIII-display formats
  • Selection and screening stratety based on specific project requirements
    • Recombinant proteins, on cells, in vivo
    • Screening by single clone analysis and/or NGS
    • Binding and/or functional assays
  • Peptide synthesis and characterization of affinity, specificity, activity
  • Chemical SAR and modification to gain in vivo stability
  • DMPK
FIND OUT MORE ABOUT OUR CROSS FUNCTIONAL DRUG DISCOVERY SERVICES

ANTIBODY
PHAGE DISPLAY

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