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IRBM’s screening library comprises over 350,000 compounds that have been carefully curated from diverse sources, including niche and mainstream suppliers or synthesized in-house. The library includes both lead-like and drug-like structures with desirable calculated properties (e.g. mean molecular weight 383 Daltons, HBD 1.46, TPSA 78) that maximize the chance of generating valid hits for your project. It is also balanced in terms of structural diversity and redundancy (i.e. the number of ‘shots-on-goal’ for any given structural class).

INFOGRAPHIC with the IRBM Compound Collection

The collection evolves every year, with a focus on structural diversity, molecular properties, 3D-ness and quality. Throughout the evolution of our collection, particular attention has been dedicated to minimizing the number of reactive, promiscuous (e.g. PAIN’s) or otherwise undesirable compounds. These are detrimental to successful high throughput screening campaigns. Although it’s challenging to completely avoid such groups, only a very low percentage (< 2%) of the total compounds are flagged as containing undesirable functionality.

INFOGRAPHIC showing the high structural diversity and focused subsets within the IRBM compound library

IRBM also offers a range of sub-libraries generated through in-house computational chemistry and by acquiring compounds with demonstrated activity toward the target of interest or specific areas of applications. Representative examples include:

  • RNA-binding subset
  • Natural product subset
  • Clinical oncology subset
  • FDA approved library
  • Epigenetic subset
  • CNS subset
  • Fragments collection

We’ve been successful in applying our library in screening campaigns against challenging targets, including protein-protein interactions, phosphatases and in a number of cell-based phenotypic screens.  The full library is available for either internal screening at IRBM or as assay-ready plates for the client’s own in-house testing requirements.

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