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At IRBM we combine creative thinking and first-class synthetic chemistry capabilities. This creates the ideal environment to transform ideas into tangible and testable compounds. Our analytical support and purification technologies drive streamlined synthetic processes that minimize cycle times and will accelerate your SAR exploration. We use our state-of-the-art infrastructure to switch, as required, to parallel synthesis with robotic and manual systems to produce small, single-point, diversity-focused libraries.

Our expert team has a strong track record in solving synthetic chemistry problems and we’ll rise to your synthetic challenge, whether it’s to produce deuterated steroids, complex macrocycles, nucleoside analogs or peptidomimetics.

IRBM’s chemistry laboratories are comprehensively equipped (including synthetic, analytic and purification technologies) to optimize throughput and maximize efficiency. We also have a dedicated scale-up laboratory to ensure all key synthetic intermediates are amplified to support late-stage optimization phases.

We use leading-edge synthetic reactions, including single electron transfer processes, photoredox, and electrochemistry to rapidly evaluate cross-coupling approaches and integrate them into a synthetic design protocol or use them as a tool to expand the chemical space.

All lead compounds undergo rigorous quality control and full structural and compositional characterization using the full spectrum of analytical techniques.

Our state-of-the-art mass spectroscopy instruments coupled to HPLC ensure we apply the widest range of MS-based analytical approaches which extends to HRMS determinations and mass-mass fragmentations.

IRBM’s NMR specialists routinely employ a recently upgraded 400 MHz spectrometer and when more in-depth characterisation is needed, our higher field NMR platforms, specifically 500 MHz and 600 MHz Brucker spectrometers, provide the ideal analytical tools. We can also develop a bespoke analytical solutions tailored to your test compound.

OUR SYNTHETIC, ANALYTICAL AND PURIFICATION APPROACHES INCLUDE:

  • Chiral and high-pressure hydrogenations
  • Parallel chemistry
  • Photoredox/ SET technologies and cross-coupling reactions
  • Electrochemistry
  • Multiple Biotage purification stations including high-capacity options
  • Multiple mass-coupled UPLC and UPC2 systems
  • Dedicated purification team using multiple reverse phase stations (FractionLynx) and SFC
  • TECAN liquid handler for parallel synthesis
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