AACR 2025April 2025OncologySmall moleculesPoster code 25010
About this poster
This poster outlines the discovery and characterization of I-1000233, a brain-penetrant, orally available SHP2 allosteric inhibitor. The compound demonstrates activity in preclinical models of primary brain tumors and CNS metastases driven by RTK/RAS/ERK pathway dysregulation. Data on in vitro potency, in vivo efficacy, and initial insights into potential responder populations are presented.
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Brain SHP2 Inhibitor poster, code 25010
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