C3PO: Complex 3D Patient Organoids for Preclinical Compound Testing in Brain Tumors

About this poster

This poster presents the development of C3PO—complex 3D patient-derived glioblastoma organoids designed to replicate the cellular and structural heterogeneity of the tumor microenvironment. Integrating glioma stem-like cells with stromal and neural components, these models enable pharmacological evaluation of therapeutic candidates under conditions that more closely reflect the in vivo tumor setting than classical monolayer and monoculture systems. Examples include compound testing with SHP2 and EGFR inhibitors across stratified GBM models, supporting both efficacy profiling and responder identification.