Discovery of I-1000233, a Potent, Selective, and Brain Permeable SHP2 Allosteric Inhibitor

About this poster

In this poster, we present the discovery of I-1000233, a potent and selective SHP2 allosteric inhibitor with excellent brain permeability. I-1000233 demonstrates strong antiproliferative effects in RAS- and EGFR-driven cancer cell lines and glioblastoma xenograft models. With its ability to cross the blood-brain barrier and favorable drug-like properties, this compound shows significant potential for the treatment of brain tumors and metastases.