About this poster
In this poster, we present IRBM’s small-molecule discovery platforms designed to address previously "undruggable" targets through novel mechanisms of action. We describe how our expanded internal libraries (~420K compounds) and technologies support rapid hit identification, leading to the selection of promising degraders and covalent inhibitors. The PROTAC screening platform enables a "Direct to Biology" (D2B) approach by pairing POI ligands with a tailored ProtoDegron library, while the covalent fragment platform identifies starting points for target-specific covalent inhibitors. Follow-up studies will assess potency, selectivity, and developability, and these evaluations are ongoing.
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Rapid hit identificaton poster, code 25005