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From Chimeric Fragments to Functional Degraders: A Streamlined Platform for PROTAC Discovery

IRBM poster 25019, preview
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PROTACs represent a transformative strategy for degrading disease-relevant proteins, but their development is often resource-intensive and slow. This poster introduces an automated platform designed to accelerate the discovery of novel degraders by integrating direct-to-biology evaluation. With a dedicated ProtoDegron library and optimized workflows for rapid assembly and profiling, the approach offers a more efficient path toward expanding PROTAC discovery.

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