Generation and Biophysical Characterization of New α-Nsp13 Helicase mAbs, as a Powerful Tool for Studying SARS-CoV-2 Replication and Therapeutic Targeting

About this poster

This poster presents the generation and biophysical characterization of novel rabbit-derived monoclonal antibodies against the SARS-CoV-2 NSP13 helicase, a highly conserved and essential component of the viral replication complex. These antibodies show high affinity and specificity, and have been validated in Western Blot and immunoassay formats. Their development addresses a critical gap in tools for studying helicase-targeting antivirals, enabling more precise investigation of NSP13 function and mechanism of action in cellular models.