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One-Pot Solution-Phase Strategy for the Synthesis of Bicyclic Peptides Using the T3P/[Pd(PPh₃)₄] System

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Macrolactam peptides are an emerging therapeutic modality suited to complex, traditionally undruggable targets, yet their synthesis remains difficult and often constrains their potential in drug discovery. This poster presents IRBM’s streamlined strategy for bicyclic peptide production, developed to overcome the recurring obstacles of multistep synthesis while improving efficiency, reproducibility, and scalability. By simplifying a traditionally demanding route, the approach broadens practical access to conformationally constrained peptides for therapeutic development. Download the poster to explore how this strategy eases the main constraints of bicyclic peptide synthesis.

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