Phenotypic Screen to Identify Inhibitors of Coronavirus Discontinuous Transcription

About this poster

Coronaviruses rely on a unique process called discontinuous transcription to generate subgenomic RNAs essential for viral replication. This poster introduces a stable cell-based model of coronavirus replication, designed with a SARS-CoV replicon and NanoLuciferase reporter, enabling high-throughput screening for inhibitors of this process. Learn how phenotypic screening, supported by extensive follow-up assays, provides a framework for discovering potential pan-coronavirus antivirals.