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Publications 2017

Structure-Based Identification of HIV-1 Nucleocapsid Protein Inhibitors Active against Wild-Type and Drug-Resistant HIV-1 Strains.

Mori M, Kovalenko L, Malancona S, Saladini F, De Forni D, Pires M, Humbert N, Real E, Botzanowski T, Cianférani S, Giannini A, Dasso Lang MC, Cugia G, Poddesu B, Lori F, Zazzi M, Harper S, Summa V, Mely Y, Botta M. (2017)
ACS Chem Biol. 2017 Dec 28.

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Phosphorylation of huntingtin at residue T3 is decreased in Huntington’s disease and modulates mutant huntingtin protein conformation.

Cariulo C, Azzollini L, Verani M, Martufi P, Boggio R, Chiki A, Deguire SM, Cherubini M, Gines S, Marsh JL, Conforti P, Cattaneo E, Santimone I, Squitieri F, Lashuel HA, Petricca L, Caricasole A. (2017)
Proc Natl Acad Sci U S A. 2017 Dec 12;114(50):E10809-E10818.

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Validation of Ultrasensitive Mutant Huntingtin Detection in Human Cerebrospinal Fluid by Single Molecule Counting Immunoassay.

Fodale V, Boggio R, Daldin M, Cariulo C, Spiezia MC, Byrne LM, Leavitt BR, Wild EJ, Macdonald D, Weiss A, Bresciani A. (2017)
J Huntingtons Dis. 2017;6(4):349-361.

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Largazole Analogues as Histone Deacetylase Inhibitors and Anticancer Agents: An Overview of Structure-Activity Relationships.

Poli G, Di Fabio R, Ferrante L, Summa V, Botta M. (2017)
ChemMedChem. 2017 Dec 7;12(23):1917-1926.

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Insights on the conformational dynamics of human frataxin through modifications of loop-1.

Noguera ME, Aran M, Smal C, Vazquez DS, Herrera MG, Roman EA, Alaimo N, Gallo M, Santos J. (2017)
Arch Biochem Biophys. 2017 Dec 15;636:123-137.

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Vitamin B12 ameliorates the phenotype of a mouse model of DiGeorge syndrome.

Lania G, Bresciani A, Bisbocci M, Francone A, Colonna V, Altamura S, Baldini A. (2017)
Hum Mol Genet. 2017 Nov 15;26(22):4540.

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Discovery by organism based high-throughput screening of new multi-stage compounds affecting Schistosoma mansoni viability, egg formation and production.

Guidi A, Lalli C, Gimmelli R, Nizi E, Andreini M, Gennari N, Saccoccia F, Harper S, Bresciani A, Ruberti G. (2017)
PLoS Negl Trop Dis. 2017 Oct 6;11(10):e0005994.

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Nuclear factor (erythroid-derived 2)-like 2 (NRF2) drug discovery: Biochemical toolbox to develop NRF2 activators by reversible binding of Kelch-like ECH-associated protein 1 (KEAP1).

Bresciani A, Missineo A, Gallo M, Cerretani M, Fezzardi P, Tomei L, Cicero DO, Altamura S, Santoprete A, Ingenito R, Bianchi E, Pacifici R, Dominguez C, Munoz-Sanjuan I, Harper S, Toledo-Sherman L, Park LC. (2017)
Arch Biochem Biophys. 2017 Oct 1;631:31-41.

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Polyglutamine expansion affects huntingtin conformation in multiple Huntington’s disease models.

Daldin M, Fodale V, Cariulo C, Azzollini L, Verani M, Martufi P, Spiezia MC, Deguire SM, Cherubini M, Macdonald D, Weiss A, Bresciani A, Vonsattel JG, Petricca L, Marsh JL, Gines S, Santimone I, Marano M, Lashuel HA, Squitieri F, Caricasole A. (2017)
Sci Rep. 2017 Jul 11;7(1):5070.

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High-Affinity “Click” RGD Peptidomimetics as Radiolabeled Probes for Imaging av ß3 Integrin.

Piras M, Testa A, Fleming IN, Dall’Angelo S, Andriu A, Menta S, Mori M, Brown GD, Forster D, Williams KJ, Zanda M. (2017)
ChemMedChem. 2017 Jul 20;12(14):1142-1151.

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PINK1 and BECN1 relocalize at mitochondria-associated membranes during mitophagy and promote ER-mitochondria tethering and autophagosome formation.

Gelmetti V, De Rosa P, Torosantucci L, Marini ES, Romagnoli A, Di Rienzo M, Arena G, Vignone D, Fimia GM, Valente EM. (2017)
Autophagy. 2017 Apr 3;13(4):654-669.

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Identification by High-Throughput Screening of Pseudomonas Acyl-Coenzyme A Synthetase Inhibitors.

Turcano L, Visaggio D, Frangipani E, Missineo A, Andreini M, Altamura S, Visca P, Bresciani A. (2017)
SLAS Discov. 2017 Aug;22(7):897-905.

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Understanding the Molecular Determinant of Reversible Human Monoamine Oxidase B Inhibitors Containing 2H-Chromen-2-One Core: Structure-Based and Ligand-Based Derived Three-Dimensional Quantitative Structure-Activity Relationships Predictive Models.

Mladenovic M, Patsilinakos A, Pirolli A, Sabatino M, Ragno R. (2017)
J Chem Inf Model. 2017 Apr 24;57(4):787-814.

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Mitotic cell death induction by targeting the mitotic spindle with tubulin-inhibitory indole derivative molecules.

Di Cesare E, Verrico A, Miele A, Giubettini M, Rovella P, Coluccia A, Famiglini V, La Regina G, Cundari E, Silvestri R, Lavia P. (2017)
Oncotarget. 2017 Mar 21;8(12):19738-19759.

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An efficient liquid chromatography-high resolution mass spectrometry approach for the optimization of the metabolic stability of therapeutic peptides.

Esposito S, Mele R, Ingenito R, Bianchi E, Bonelli F, Monteagudo E, Orsatti L. (2017)
Anal Bioanal Chem. 2017 Apr;409(10):2685-2696.

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