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Publications 2019

Application of an in Vitro Blood−Brain Barrier Model in the Selection of Experimental Drug Candidates for the Treatment of Huntington’s Disease

Annalise Di Marco, Odalys Gonzalez Paz, Ivan Fini, Domenico Vignone, Antonella Cellucci, Maria Rosaria Battista, Giulio Auciello, Laura Orsatti, Matteo Zini, Edith Monteagudo, Vinod Khetarpal, Mark Rose, Celia Dominguez, Todd Herbst, Leticia Toledo-Sherman, Vincenzo Summa and Ignacio Muñoz-Sanjuán
Mol. Pharmaceutics 2019, 16, 2069−2082

Identification of Isoform 2 Acid-Sensing Ion Channel Inhibitors as Tool Compounds for Target Validation Studies in CNS

Leda Ivanova Bencheva, Marilenia De Matteo, Luca Ferrante, Marco Ferrara, Adolfo Prandi, Pietro Randazzo, Silvano Ronzoni, Roberta Sinisi, Pierfausto Seneci, Vincenzo Summa, Mariana Gallo, Maria Veneziano§ Antonella Cellucci, Nausicaa Mazzocchi, Andrea Menegon and Romano Di Fabio
ACS Med. Chem. Lett. 2019, 10, 627−632

Developmental abnormalities in cortical GABAergic system in mice lacking mGlu3 metabotropic glutamate receptors.

Imbriglio T, Verhaeghe R, Martinello K, Pascarelli MT, Chece G, Bucci D, Notartomaso S, Quattromani M, Mascio G, Scalabrì F, Simeone A, Maccari S, Del Percio C, Wieloch T, Fucile S, Babiloni C, Battaglia G, Limatola C, Nicoletti F, Cannella M.
FASEB J. 2019 Oct 30:fj201901093RRR

Multiple Synthetic Routes to the Mini-Protein Omomyc and Coiled-coil Domain Truncations.

Brown ZZ, Mapelli C, Farasat I, Shoultz AV, Orvieto F, Santoprete A, Bianchi E, Johnson SA, McCracken AB, Chen K, Zhu X, Demma MJ, Lacey BM, Canada KA, Garbaccio RM, O’Neil J, Walji A.
J Org Chem. 2019 Oct 29.

Omomyc Reveals New Mechanisms To Inhibit the MYC Oncogene.

Demma MJ, Mapelli C, Sun A, Bodea S, Ruprecht B, Javaid S, Wiswell D, Muise E, Chen S, Zelina J, Orvieto F, Santoprete A, Altezza S, Tucci F, Escandon E, Hall B, Ray K, Walji A, O’Neil J.
Mol Cell Biol. 2019 Oct 28;39(22). pii: e00248-19.

Aspergillus olivimuriae sp. nov., a halotolerant species isolated from olive brine.

Crognale S, Pesciaroli L, Felli M, Petruccioli M, D’Annibale A, Bresciani A, Peterson SW.
Int J Syst Evol Microbiol. 2019 Sep;69(9):2899-2906.

Phospho-S129 Alpha-Synuclein Is Present in Human Plasma but Not in Cerebrospinal Fluid as Determined by an Ultrasensitive Immunoassay.

Cariulo C, Martufi P, Verani M, Azzollini L, Bruni G, Weiss A, Deguire SM, Lashuel HA, Scaricamazza E, Sancesario GM, Schirinzi T, Mercuri NB, Sancesario G, Caricasole A, Petricca L.
Front Neurosci. 2019 Aug 22;13:889

Fish-derived antimicrobial peptides: Activity of a chionodracine mutant against bacterial models and human bacterial pathogens.

Buonocore F, Picchietti S, Porcelli F, Della Pelle G, Olivieri C, Poerio E, Bugli F, Menchinelli G, Sanguinetti M, Bresciani A, Gennari N, Taddei AR, Fausto AM, Scapigliati G.
Dev Comp Immunol. 2019 Jul;96:9-17

Salivary Metabolome and Soccer Match: Challenges for Understanding Exercise induced Changes.

Pitti E, Petrella G, Di Marino S, Summa V, Perrone M, D’Ottavio S, Bernardini A, Cicero DO.
Metabolites. 2019 Jul 11;9(7). pii: E141.

Development and characterization of cellular biosensors for HTS of erythroid differentiation inducers targeting the transcriptional activity of γ-globin and β-globin gene promoters.

Breveglieri G, Salvatori F, Finotti A, Cosenza LC, Zuccato C, Bianchi N, Breda L, Rivella S, Bresciani A, Bisbocci M, Borgatti M, Gambari R.
Anal Bioanal Chem. 2019 Jul 4.

The Outcomes of Decorated Prolines in the Discovery of Antimicrobial Peptides from Temporin-L.

Buommino E, Carotenuto A, Antignano I, Bellavita R, Casciaro B, Loffredo MR, Merlino F, Novellino E, Mangoni ML, Nocera FP, Brancaccio D, Punzi P, Roversi D, Ingenito R, Bianchi E, Grieco P.
ChemMedChem. 2019 Jul 3;14(13):1283-1290.

Collagen Prolyl Hydroxylation-Dependent Metabolic Perturbation Governs Epigenetic Remodeling and Mesenchymal Transition in Pluripotent and Cancer Cells.

D’Aniello C1, Cermola F, Palamidessi A, Wanderlingh LG, Gagliardi M, Migliaccio A, Varrone F, Casalino L, Matarazzo MR, De Cesare D, Scita G, Patriarca EJ, Minchiotti G.
Cancer Res. 2019 Jul 1;79(13):3235-3250.

A novel member of Prame family, Gm12794c, counteracts retinoic acid differentiation through the methyltransferase activity of PRC2.

Napolitano G, Tagliaferri D, Fusco S, Cirillo C, De Martino I, Addeo M, Mazzone P, Russo NA, Natale F, Cardoso MC, De Luca L, Lamorte D, La Rocca F, De Felice M, Falco G-
Cell Death Differ. 2019 Jun 11.

Octreotide Conjugates for Tumor Targeting and Imaging.

Figueras E, Martins A, Borbély A, Le Joncour V, Cordella P, Perego R, Modena D, Pagani P, Esposito S, Auciello G, Frese M, Gallinari P, Laakkonen P, Steinkühler C, Sewald N.
Pharmaceutics. 2019 May 7;11(5). pii: E220.

Inhibiting pathologically active ADAM10 rescues synaptic and cognitive decline in Huntington’s disease.

Vezzoli E, Caron I, Talpo F, Besusso D, Conforti P, Battaglia E, Sogne E, Falqui A, Petricca L, Verani M, Martufi P, Caricasole A, Bresciani A, Cecchetti O, Rivetti di Val Cervo P, Sancini G, Riess O, Nguyen H, Seipold L, Saftig P, Biella G, Cattaneo E, Zuccato C.
J Clin Invest. 2019 May 6;130.

Design, Synthesis, and Biological Evaluation of New 1-(Aryl-1 H-pyrrolyl)(phenyl)methyl-1 H-imidazole Derivatives as Antiprotozoal Agent.

Saccoliti F, Madia VN, Tudino V, De Leo A, Pescatori L, Messore A, De Vita D, Scipione L, Brun R, Kaiser M, Mäser P, Calvet CM, Jennings GK, Podust LM, Pepe G, Cirilli R, Faggi C, Di Marco A, Battista MR, Summa V, Costi R, Di Santo R.
J Med Chem. 2019 Feb 14;62(3):1330-1347.

Synthesis and Biological Evaluation of RGD⁻Cryptophycin Conjugates for Targeted Drug Delivery.

Borbély A, Figueras E, Martins A, Esposito S, Auciello G, Monteagudo E, Di Marco A, Summa V, Cordella P, Perego R, Kemker I, Frese M, Gallinari P, Steinkühler C, Sewald N.
Pharmaceutics 2019, 11(4), 151.

A novel method using nuclear magnetic resonance for plasma proteinbinding assessment in drug discovery programs.

Gallo M, Matteucci S, Alaimo N, Pitti E, Orsale MV, Summa V, Cicero DO, Monteagudo E.
Journal of Pharmaceutical and Biomedical Analysis 167 (2019) 21–29.

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