SAR evolution towards potent C-terminal carboxamide peptide inhibitors of Zika virus NS2B-NS3 protease
Zika virus (ZIKV) is a member of the Flaviviridae family that can cause neurological disorders and congenital malformations.
At IRBM, we are aware that a screening campaign’s success is critically dependent on the quality and reproducibility of the assays used. Together with the NIH, academic institutions and pharmaceutical companies, we are participating in an EATRIS consortium initiative to help investigate this issue. This collaboration is the first systematic study by translational scientists into the reproducibility of high-throughput screening (HTS) campaigns.
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