skip to Main Content

IRBM’s drug discovery research is featured on the cover of this issue’s ACS Publications’ Medicinal Chemistry Letters

Katritzky Salts for the Synthesis of Unnatural Amino Acids and Late-Stage Functionalization of Peptides

The publication describes the discovery of a novel series of Imidazopyrazine derivatives by IRBM’s drug discovery team. This novel series of SHP2 allosteric inhibitors, having an imidazopyrazine 6,5-fused heterocyclic system as central scaffold, showed an excellent potency in enzyme and cellular assays. X-ray studies confirmed novel stabilizing interactions with respect to known SHP2 inhibitors. These compounds paved the way to the discovery of preclinical candidates.

Back To Top