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New IRBM Contribution To The Journal Of Clinical Investigation

New IRBM Contribution to the Journal of Clinical Investigation

A new paper by IRBM scientists, in collaboration with an international team, has been published in Journal of Clinical Investigation. The team found out that in the presence of the polyglutamine-expanded huntingtin protein, the metalloproteinase ADAM10 accumulates in synapses and causes synaptic defects, both in vitro and in vivo. However, inhibition of ADAM10 ameliorates appears to restore proper synaptic function in vitro, and to restore cognitive deficits in in vivo models. As a result, this exciting study shows therapeutic potential for ADAM10 inhibition in the treatment of Huntington’s disease.

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