Oxidative stress has been associated with pathogenesis in several diseases including Huntington's disease (HD), a neurodegenerative disorder caused by a mutation in the huntingtin gene. Oxidative stress induced reactive oxygen species (ROS) are normally controlled at the cellular level by…
Huntington's disease (HD) is a monogenetic neurodegenerative disorder that is caused by the expansion of a polyglutamine region within the huntingtin (HTT) protein, but there is still an incomplete understanding of the molecular mechanisms that drive pathology. Expression of the…
Mutations in the human PANK2 gene are implicated in neurodegenerative diseases such as pantothenate kinase-associated neurodegeneration (PKAN) and result in low levels of coenzyme-A (CoA) in the CNS due to impaired production of phosphopantothenic acid (PPA) from vitamin B5. Restoration…
M. Venanzi, M. Savioli, R. Cimino, E. Gatto, A. Palleschi, G. Ripani, D. Cicero, E. Placidi, F. Orvieto and E. Bianchi
Stefania Colarusso, Daniele De Simone, Tommaso Frattarelli, Matteo Andreini, Mauro Cerretani, Antonino Missineo, Daniele Moretti, Sara Tambone, Georg Kempf, Martin Augustin, Stefan Steinbacher, Ignacio Munoz-Sanjuan, Larry Park, Vincenzo Summa, Licia Tomei, Alberto Bresciani, Celia Dominguez, Leticia Toledo-Sherman, Elisabetta Bianchi
Science advances by collaborations and publications. Over the last decade, IRBM has done significant research into neurodegenerative diseases such as Huntington’s disease (HD), often with our excellent collaborators at the CHDI Foundation, and other esteemed institutions. Our paper in J.…
