IRBM publish malaria breakthrough research in Nature Communications Biology
SAR evolution towards potent C-terminal carboxamide peptide inhibitors of Zika virus NS2B-NS3 protease
Efficacy of PEGylated ciliary neurotrophic factor superagonist variant in diet-induced obesity mice
NRF2 activation by reversible KEAP1 binding induces the antioxidant response in primary neurons and astrocytes of a Huntington’s disease mouse model
Oxidative stress has been associated with pathogenesis in several diseases including Huntington's disease (HD), a neurodegenerative disorder caused by a mutation in the huntingtin gene. Oxidative stress induced reactive oxygen species (ROS) are normally controlled at the cellular level by…
Analysis of mutant and total huntingtin expression in Huntington’s disease murine models
Huntington's disease (HD) is a monogenetic neurodegenerative disorder that is caused by the expansion of a polyglutamine region within the huntingtin (HTT) protein, but there is still an incomplete understanding of the molecular mechanisms that drive pathology. Expression of the…
Cyclic Phosphopantothenic Acid Prodrugs for Treatment of Pantothenate Kinase-Associated Neurodegeneration
Mutations in the human PANK2 gene are implicated in neurodegenerative diseases such as pantothenate kinase-associated neurodegeneration (PKAN) and result in low levels of coenzyme-A (CoA) in the CNS due to impaired production of phosphopantothenic acid (PPA) from vitamin B5. Restoration…
A spectroscopic and molecular dynamics study on the aggregation process of a long-acting lipidated therapeutic peptide: the case of semaglutide
M. Venanzi, M. Savioli, R. Cimino, E. Gatto, A. Palleschi, G. Ripani, D. Cicero, E. Placidi, F. Orvieto and E. Bianchi
Optimization of Linear and Cyclic Peptide Inhibitors of KEAP1-NRF2 Protein-Protein Interaction
Stefania Colarusso, Daniele De Simone, Tommaso Frattarelli, Matteo Andreini, Mauro Cerretani, Antonino Missineo, Daniele Moretti, Sara Tambone, Georg Kempf, Martin Augustin, Stefan Steinbacher, Ignacio Munoz-Sanjuan, Larry Park, Vincenzo Summa, Licia Tomei, Alberto Bresciani, Celia Dominguez, Leticia Toledo-Sherman, Elisabetta Bianchi
IRBM & CHDI Foundation publishes in J. MedChem on potential imaging biomarker for Huntington’s disease
Science advances by collaborations and publications. Over the last decade, IRBM has done significant research into neurodegenerative diseases such as Huntington’s disease (HD), often with our excellent collaborators at the CHDI Foundation, and other esteemed institutions. Our paper in J.…