Publications 2011 Archivi

Development of a scalable chiral synthesis of MK-3281, an inhibitor of the hepatitis C virus NS5B polymerase

Publications, Publications 2011

By Colarusso, Stefania; Conte, Immacolata; Di Filippo, Marcello; Ercolani, Caterina; MacKay, Angela C.; Palumbi, Maria Cecilia; Ferreira, Maria del Rosario Rico; Stansfield, Ian; Zaramella, Simone; Narjes, Frank; et al From Synlett (2011), (11), 1527-1532. Language: English, Database: CAPLUS, DOI:10.1055/s-0030-1260790 The…

Mechanistic implications for LDL receptor degradation from the PCSK9/LDLR structure at neutral pH.

Publications, Publications 2011

By Lo Surdo, Paola; Bottomley, Matthew J.; Calzetta, Alessandra; Settembre, Ethan C.; Cirillo, Agostino; Pandit, Shilpa; Ni, Yan G.; Hubbard, Brian; Sitlani, Ayesha; Carfi, Andrea From EMBO Reports (2011), 12(12), 1300-1305. Language: English, Database: CAPLUS, DOI:10.1038/embor.2011.205 The protein PCSK9 (proprotein…

Structure of herpes simplex virus glycoprotein D bound to the human receptor nectin-1.

Publications, Publications 2011

By Di Giovine, Paolo; Settembre, Ethan C.; Bhargava, Arjun K.; Luftig, Micah A.; Lou, Huan; Cohen, Gary H.; Eisenberg, Roselyn J.; Krummenacher, Claude; Carfi, Andrea From PLoS Pathogens (2011), 7(9), e1002277. Language: English, Database: CAPLUS, DOI:10.1371/journal.ppat.1002277 Binding of herpes simplex…

Identification of a series of 4-[3-(quinolin-2-yl)-1,2,4-oxadiazol-5-yl]piperazinyl ureas as potent smoothened antagonist hedgehog pathway inhibitors.

Publications, Publications 2011

By Ontoria, Jesus M.; Bufi, Laura Llauger; Torrisi, Caterina; Bresciani, Alberto; Giomini, Claudia; Rowley, Michael; Serafini, Sergio; Bin, Hu; Hao, Wu; Steinkuehler, Christian; et al From Bioorganic & Medicinal Chemistry Letters (2011), 21(18), 5274-5282. Language: English, Database: CAPLUS, DOI:10.1016/j.bmcl.2011.07.031 The…

N-(2-alkylaminoethyl)-4-(1,2,4-oxadiazol-5-yl)piperazine-1-carboxamides as highly potent smoothened antagonists.

Publications, Publications 2011

By Muraglia, Ester; Ontoria, Jesus M.; Branca, Danila; Dessole, Gabriella; Bresciani, Alberto; Fonsi, Massimiliano; Giuliano, Claudio; Llauger Bufi, Laura; Monteagudo, Edith; Palumbi, Maria Cecilia; et al From Bioorganic & Medicinal Chemistry Letters (2011), 21(18), 5283-5288. Language: English, Database: CAPLUS, DOI:10.1016/j.bmcl.2011.07.030…

Identification of MK-5710 ((8aS)-8a-methyl-1,3-dioxo-2-[(1S,2R)-2-phenylcyclopropyl]-N-(1-phenyl-1H-pyrazol-5-yl)hexahydroimid azo[1,5-a]pyrazine-7(1H)-carboxamide), a potent smoothened antagonist for use in Hedgehog pathway dependent malignancies, part 1.

Publications, Publications 2011

By Malancona, Savina; Altamura, Sergio; Filocamo, Gessica; Kinzel, Olaf; Hernando, Jose Ignacio Martin; Rowley, Michael; Scarpelli, Rita; Steinkuehler, Christian; Jones, Philip From Bioorganic & Medicinal Chemistry Letters (2011), 21(15), 4422-4428. Language: English, Database: CAPLUS, DOI:10.1016/j.bmcl.2011.06.024 The Hedgehog (Hh-) signaling pathway…

Identification of MK-5710 ((8aS)-8a-methyl-1,3-dioxo-2-[(1S,2R)-2-phenylcyclo- propyl]-N-(1-phenyl-1H-pyrazol-5-yl)hexahydro-imidazo[1,5-a]pyrazine-7(1H)-carboxamide), a potent smoothened antagonist for use in Hedgehog pathway dependent malignancies, part 2.

Publications, Publications 2011

By Kinzel, Olaf; Alfieri, Anna; Altamura, Sergio; Brunetti, Mirko; Bufali, Simone; Colaceci, Fabrizio; Ferrigno, Federica; Filocamo, Gessica; Fonsi, Massimiliano; Gallinari, Paola; et al From Bioorganic & Medicinal Chemistry Letters (2011), 21(15), 4429-4435. Language: English, Database: CAPLUS, DOI:10.1016/j.bmcl.2011.06.023 The Hedgehog (Hh-)…

Intratumor RNA interference of cell cycle genes slows down tumor progression.

Publications, Publications 2011

By Dharmapuri, S.; Peruzzi, D.; Marra, E.; Palombo, F.; Bett, A. J.; Bartz, S. R.; Yong, M.; Ciliberto, G.; La Monica, N.; Buser, C. A.; et al From Gene Therapy (2011), 18(7), 727-733. Language: English, Database: CAPLUS, DOI:10.1038/gt.2011.27 Small interfering…