Development of a scalable chiral synthesis of MK-3281, an inhibitor of the hepatitis C virus NS5B polymerase

By Colarusso, Stefania; Conte, Immacolata; Di Filippo, Marcello; Ercolani, Caterina; MacKay, Angela C.; Palumbi, Maria Cecilia; Ferreira, Maria del Rosario Rico; Stansfield, Ian; Zaramella, Simone; Narjes, Frank; et al
From Synlett (2011), (11), 1527-1532. Language: English, Database: CAPLUS, DOI:10.1055/s-0030-1260790

The development of a scalable chiral synthesis for the HCV NS5B inhibitor MK-3281 I is being reported. Several alternative routes were explored and are being described.