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Polyglutamine- and temperature-dependent conformational rigidity in mutant huntingtin revealed by immunoassays and circular dichroism spectroscopy

By Fodale, Valentina; Kegulian, Natalie C.; Verani, Margherita; Cariulo, Cristina; Azzollini, Lucia; Petricca, Lara; Daldin, Manuel; Boggio, Roberto; Padova, Alessandro; Kuhn, Rainer; et al From PLoS One (2014), 9(12), e112262/1-e112262/31, 31 pp.. Language: English, Database: CAPLUS, DOI:10.1371/journal.pone.0112262 In Huntington's disease,…

Development of a neuromedin U-human serum albumin conjugate as a long-acting candidate for the treatment of obesity and diabetes. Comparison with the PEGylated peptide.

By Neuner, Philippe; Peier, Andrea M.; Talamo, Fabio; Ingallinella, Paolo; Lahm, Armin; Barbato, Gaetano; Di Marco, Annalise; Desai, Kunal; Zytko, Karolina; Qian, Ying; et al From Journal of Peptide Science (2014), 20(1), 7-19. Language: English, Database: CAPLUS, DOI:10.1002/psc.2582 Neuromedin U…

Immunogenicity and therapeutic efficacy of a dual-component genetic cancer vaccine cotargeting carcinoembryonic antigen and HER2/neu in preclinical models.

By Aurisicchio, Luigi; Peruzzi, Daniela; Koo, Gloria; Wei, Wei-Zen; La Monica, Nicola; Ciliberto, Gennaro From Human Gene Therapy (2014), 25(2), 121-131. Language: English, Database: CAPLUS, DOI:10.1089/hum.2013.103 Several cancer vaccine efforts have been directed to simultaneously cotarget multiple tumor antigens, with…

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