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Peptidomimetic nitrile inhibitors of malarial protease falcipain-2 with high selectivity against human cathepsins.

By Nizi, Emanuela; Sferrazza, Alessio; Fabbrini, Danilo; Nardi, Valentina; Andreini, Matteo; Graziani, Rita; Gennari, Nadia; Bresciani, Alberto; Paonessa, Giacomo; Harper, Steven From Bioorganic & Medicinal Chemistry Letters (2018), 28(9), 1540-1544. Language: English, Database: CAPLUS, DOI:10.1016/j.bmcl.2018.03.069 Falcipain-2 (FP2) is an essential…

Quantifying autophagy using novel LC3B and p62 TR-FRET assays.

By Bresciani, Alberto; Spiezia, Maria Carolina; Boggio, Roberto; Cariulo, Cristina; Nordheim, Anja; Altobelli, Roberta; Kuhlbrodt, Kirsten; Dominguez, Celia; Munoz-Sanjuan, Ignacio; Wityak, John; et al From PLoS One (2018), 13(3), e0194423/1-e0194423/18. Language: English, Database: CAPLUS, DOI:10.1371/journal.pone.0194423 Autophagy is a cellular mechanism…

Fosmetpantotenate (RE-024), a phosphopantothenate replacement therapy for pantothenate kinase-associated neurodegeneration: Mechanism of action and efficacy in nonclinical models.

By Elbaum Daniel; Beconi Maria G; Quinton Maria S; Vaino Andrew; Monteagudo Edith; Di Marco Annalise; Lyons Kathryn A; Harper Steven From PloS one (2018), 13(3), e0192028, Language: English, Database: MEDLINE In cells, phosphorylation of pantothenic acid to generate phosphopantothenic…

Discovery of 2-(1H-imidazo-2-yl)piperazines as a new class of potent and non-cytotoxic inhibitors of Trypanosoma brucei growth in vitro

By Ferrigno, Federica; Biancofiore, Ilaria; Malancona, Savina; Ponzi, Simona; Paonessa, Giacomo; Graziani, Rita; Bresciani, Alberto; Gennari, Nadia; Di Marco, Annalise; Kaiser, Marcel; et al From Bioorganic & Medicinal Chemistry Letters (2018), 28(23-24), 3689-3692. Language: English, Database: CAPLUS, DOI:10.1016/j.bmcl.2018.10.028 The identification…

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