We have had long, productive relationships with many organizations who share our passion for impacting the field of neuroscience, where developing therapeutics is a major scientific and clinical challenge. Our focus has been largely on protein misfolding diseases of the central nervous system (CNS), which cause the brain’s nerve cells to break down, resulting in the deterioration of physical, mental, and emotional abilities.
Because understanding protein therapeutics is a core expertise, we track down drugs that can reduce the accumulation of mutant proteins, a primary pathological event leading to loss of biological function in several CNS disorders including Alzheimer’s Disease, Machado-Joseph Disease (SCA-3) and Parkinson’s.
Finding biomarkers for, and drugs to treat, the neurodegenerative disorder Huntington’s Disease is a specific neuroscience specialty for IRBM, and we have worked with numerous organizations working in this field to push forward the neuroscience frontier, providing insights into disease biology.
We cover the whole range of neuroscience drug discovery phases from target validation through to candidate nomination. In the tables below we list our toolbox of capabilities we can apply to your program.
ASSAYS
- Protein levels (mutant HTT and total HTT, SNCA, ATXN3)
- Protein T1/2 (HTT)
- Oligomerization/aggregation (imaging and biochemical; HTT)
- Subcellular localization (imaging and biochemical; HTT)
- Viability and functional readouts in primary rodent neurons (imaging and biochemical)
- Neurite outgrowth
MODELS
- Primary neuronal cultures from rodents
- Human ES/iPS cells, NPCs and derived neurons
OTHER RELEVANT TOOLS
- MDCK (non endothelial cell based model) a high throughput screen general permeation behaviour of compounds, in a cellular setup and their susceptibility to drug efflux.
- Human In vitro BBB model derived from iPSCs which can investigate the permeability of small molecules and biologics as well as the evaluation of delivery strategies.
- Neuro-focussed compound library that can be screened together with our diverse compound library containing over 320,000 compounds with fully automated compound management
If you are looking for molecular insights into the mode of action of your potential CNS therapeutic, or whether it crosses the BBB, or a novel target for which you want to develop a therapeutic, talk to us. We have the analytical expertise to help you create the CNS medicine of tomorrow.
Relevant Publications
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